NONO

Across TCGA cell cohorts, NONO RNA expression is significantly associated with the go_rna of many other GO terms, with 5,226 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible NONO-associated GO terms across cancer lineages are Mitotic spindle elongation, Mitotic spindle midzone assembly, and Constitutive heterochromatin formation. Each is linked with NONO in more than 17 cancer types. Because this analysis shows association rather than direction, both NONO-to-partner and partner-to-NONO results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Mitotic spindle elongation grouped by NONO-low versus NONO-high in SKIN.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (NONO→partner) and Y-score (partner→NONO) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	Mitotic spindle elongation →	+0.214	+0.657	<.001	.003	3	18
SKIN	Mitotic spindle midzone assembly →	+0.214	+0.657	<.001	.003	3	18
LUNG_SCLC	Constitutive heterochromatin formation →	+0.123	+0.731	<.001	<.001	3	17
PANCREAS	U2-type prespliceosome assembly →	+0.125	+1.081	<.001	<.001	3	17
SOFT_TISSUE	Interstrand cross-link repair →	+0.088	+0.695	<.001	<.001	3	17
BONE	DNA strand elongation →	+0.182	+0.966	.006	.002	3	17

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,226 associations by consensus.

Mitotic spindle elongation by NONO expression — SKIN

Explore this box plot interactively →