NONO

Across TCGA cell cohorts, NONO mutation is significantly associated with the RNA expression of many other genes, with 11 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible NONO-associated genes across cancer lineages are HIGD2B, FAM153B, and TAFA1. Each is linked with NONO in more than 1 cancer types. Because this analysis shows association rather than direction, both NONO-to-partner and partner-to-NONO results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, HIGD2B grouped by NONO-low versus NONO-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NONO→partner) and Y-score (partner→NONO) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	HIGD2B →	+0.049	+3.724	.002	.004	3	1
LARGE_INTESTINE	FAM153B →	+0.500	+3.618	<.001	.003	3	1
LARGE_INTESTINE	TAFA1 →	+0.234	+3.103	.002	.004	3	1
LARGE_INTESTINE	SMIM33 →	+0.718	+3.426	<.001	.007	3	1
LARGE_INTESTINE	NEXMIF →	+0.227	+3.518	<.001	.001	3	1
SKIN	SLC22A8 →	+0.027	+4.415	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 11 associations by consensus.

HIGD2B by NONO expression — LARGE_INTESTINE

Explore this box plot interactively →