NONO

Across TCGA cell cohorts, NONO mutation is significantly associated with the mutation status of many other genes, with 3,303 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible NONO-associated genes across cancer lineages are DAGLA, ZNF653, and LRRTM4. Each is linked with NONO in more than 2 cancer types. Because this analysis shows association rather than direction, both NONO-to-partner and partner-to-NONO results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DAGLA grouped by NONO-low versus NONO-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NONO→partner) and Y-score (partner→NONO) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	DAGLA →	+2.830	+3.548	.009	.009	1	3
SKIN	ZNF653 →	+5.053	+4.239	.007	.007	1	3
SKIN	LRRTM4 →	+3.638	+4.117	.002	.002	1	3
BLOOD_Lymphoma	SRSF11 →	+6.014	+6.014	.001	.001	1	3
BLOOD_Lymphoma	B4GALT2 →	+5.014	+5.584	.003	.003	1	3
BLOOD_Lymphoma	FLT3 →	+4.429	+5.247	.005	.005	1	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,303 associations by consensus.

DAGLA by NONO expression — SKIN

Explore this box plot interactively →