NOMO3

Across TCGA patient cohorts, NOMO3 mutation is significantly associated with the total protein of many other genes, with 14 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NOMO3-associated genes across cancer lineages are EGFR_pY1068, eIF4E, and ACC1. Each is linked with NOMO3 in more than 1 cancer types. Because this analysis shows association rather than direction, both NOMO3-to-partner and partner-to-NOMO3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR_pY1068 grouped by NOMO3-low versus NOMO3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NOMO3→partner) and Y-score (partner→NOMO3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.256	-2.807	.019	.003	3	1
UCEC	eIF4E →	+0.197	+2.820	.032	.035	3	1
UCEC	ACC1 →	+0.363	+3.013	.022	.018	3	1
UCEC	MEK1 →	+0.394	+2.459	.013	.019	3	1
UCEC	PDCD4 →	-0.472	-2.999	.021	.035	3	1
UCEC	PDK1_pS241 →	+0.193	+3.584	.009	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 14 associations by consensus.

EGFR_pY1068 by NOMO3 expression — UCEC

Explore this box plot interactively →