NOMO1

Across TCGA patient cohorts, NOMO1 mutation is significantly associated with the total protein of many other genes, with 33 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NOMO1-associated genes across cancer lineages are GAPDH, EGFR_pY1068, and Rab25. Each is linked with NOMO1 in more than 1 cancer types. Because this analysis shows association rather than direction, both NOMO1-to-partner and partner-to-NOMO1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GAPDH grouped by NOMO1-low versus NOMO1-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NOMO1→partner) and Y-score (partner→NOMO1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	GAPDH →	+0.503	+3.169	.032	.017	3	2
COAD	EGFR_pY1068 →	-0.411	-2.991	.015	.036	3	2
UCEC	Rab25 →	-0.278	-2.321	.017	.033	3	2
UCEC	ERK2 →	+0.158	+1.906	.020	.015	3	2
UCEC	mTOR_pS2448 →	-0.111	-1.886	.035	.015	3	2
UCEC	Notch1 →	+0.167	+1.362	<.001	.037	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 33 associations by consensus.

GAPDH by NOMO1 expression — SKCM

Explore this box plot interactively →