NOMO1

Across TCGA cell cohorts, NOMO1 mutation is significantly associated with the RNA expression of many other genes, with 30 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible NOMO1-associated genes across cancer lineages are SIGLEC5, IL9, and OR1L3. Each is linked with NOMO1 in more than 1 cancer types. Because this analysis shows association rather than direction, both NOMO1-to-partner and partner-to-NOMO1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SIGLEC5 grouped by NOMO1-low versus NOMO1-high in BREAST.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NOMO1→partner) and Y-score (partner→NOMO1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	SIGLEC5 →	+0.019	+5.312	<.001	<.001	3	1
BREAST	IL9 →	+0.040	+4.781	<.001	.003	3	1
BREAST	OR1L3 →	+0.025	+5.754	<.001	<.001	3	1
BREAST	OR2T5 →	+0.025	+4.781	<.001	.003	3	1
BREAST	C1orf141 →	+0.037	+4.781	<.001	.003	3	1
BREAST	HIGD1C →	+0.193	+4.672	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 30 associations by consensus.

SIGLEC5 by NOMO1 expression — BREAST

Explore this box plot interactively →