NOM1

Across TCGA pan-cancer cohorts, NOM1 mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated NOM1 data layer compared with 25 for mass-spec protein and 6 for mutation status.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where higher NOM1 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated NOM1 expression acts as an unfavorable survival marker, although some lineages such as LSCC and UCEC show a favorable association.

LSCC, LUAD, and CCRCC are the cancer types where NOM1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LSCC	DFS	Median	II,III,IV	0.849	0.547	.012	22	view →
LUAD	OS	Tertile	II,III,IV	0.315	1.000	.003	20	view →
CCRCC	DFS	Tertile	III,IV	0.123	0.904	.024	9	view →
UCEC	DFS	Median	III,IV	0.904	0.445	.037	4	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

NOM1–LSCC (DFS)

Open the LSCC breakdown →