NOM1

Across TCGA patient cohorts, NOM1 mutation is significantly associated with the total protein of many other genes, with 46 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NOM1-associated genes across cancer lineages are ATM, 14-3-3_beta, and GAPDH. Each is linked with NOM1 in more than 2 cancer types. Because this analysis shows association rather than direction, both NOM1-to-partner and partner-to-NOM1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by NOM1-low versus NOM1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NOM1→partner) and Y-score (partner→NOM1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATM →	-0.492	-2.687	.001	.005	3	3
UCEC	14-3-3_beta →	-0.076	-1.673	.024	.040	3	2
UCEC	GAPDH →	+0.510	+3.700	.004	.001	3	2
UCEC	ACC1 →	+0.364	+2.598	.002	.005	3	2
UCEC	mTOR_pS2448 →	-0.120	-1.658	.016	.021	3	2
UCEC	p62 Lck ligand →	+0.497	+2.584	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 46 associations by consensus.

ATM by NOM1 expression — UCEC

Explore this box plot interactively →