NOM1

Across TCGA cell cohorts, NOM1 mutation is significantly associated with the RNA expression of many other genes, with 14 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible NOM1-associated genes across cancer lineages are MGAT4D, CFHR2, and SERPINA7. Each is linked with NOM1 in more than 1 cancer types. Because this analysis shows association rather than direction, both NOM1-to-partner and partner-to-NOM1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MGAT4D grouped by NOM1-low versus NOM1-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NOM1→partner) and Y-score (partner→NOM1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	MGAT4D →	+0.023	+4.977	<.001	.007	3	2
BLOOD_Leukemia	CFHR2 →	+0.296	+4.539	<.001	.007	3	2
SOFT_TISSUE	SERPINA7 →	+0.012	+4.930	<.001	.008	3	1
LUNG_NSCLC_LUAD	SPINT4 →	+0.054	+5.228	<.001	.005	3	1
LUNG_NSCLC_LUAD	CLDN17 →	+0.018	+5.228	<.001	.005	3	1
LUNG_NSCLC_LUAD	USP17L15 →	+0.016	+5.228	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 14 associations by consensus.

MGAT4D by NOM1 expression — SKIN

Explore this box plot interactively →