NOLC1

Across TCGA pan-cancer cohorts, NOLC1 mass-spec protein is linked to patient survival in 7 of 34 cancer types, making it a survival-associated NOLC1 data layer compared with 26 for mass-spec protein and 5 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher NOLC1 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated NOLC1 expression acts as an unfavorable survival marker, although some lineages such as LSCC and COAD show a favorable association.

CCRCC, LSCC, and COAD are the cancer types where NOLC1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	DFS	Tertile	All	0.686	0.924	.002	59	view →
LSCC	DFS	Median	II,III,IV	0.891	0.665	.008	19	view →
COAD	DFS	Median	III,IV	1.000	0.841	.041	12	view →
PDAC	DFS	Median	All	0.455	0.245	.005	10	view →
LUAD	DFS	Tertile	III,IV	0.920	0.280	.011	6	view →
GBM	OS	Tertile	All	0.656	0.319	.014	5	view →
HNSC	DFS	Median	IV	1.000	0.924	.037	1	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

NOLC1–CCRCC (DFS)

Open the CCRCC breakdown →