NOLC1

Across TCGA patient cohorts, NOLC1 mutation is significantly associated with the total protein of many other genes, with 24 significant associations in total. SKCM shows the largest number of these associations.

The most reproducible NOLC1-associated genes across cancer lineages are Cyclin-B1, PCNA, and Caspase-8. Each is linked with NOLC1 in more than 1 cancer types. Because this analysis shows association rather than direction, both NOLC1-to-partner and partner-to-NOLC1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Cyclin-B1 grouped by NOLC1-low versus NOLC1-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NOLC1→partner) and Y-score (partner→NOLC1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	Cyclin-B1 →	+0.686	+3.008	.015	.019	3	2
UCEC	PCNA →	+0.251	+2.700	.010	.006	3	2
UCEC	Caspase-8 →	-0.237	-3.295	.036	.009	3	2
SKCM	Mre11 →	+0.309	+2.832	<.001	.034	3	1
SKCM	Smac →	-0.328	-3.152	.025	.019	3	1
SKCM	Src_pY416 →	+0.412	+3.169	.013	.019	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 24 associations by consensus.

Cyclin-B1 by NOLC1 expression — COAD

Explore this box plot interactively →