NOLC1

Across TCGA cell cohorts, NOLC1 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,900 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible NOLC1-associated GO terms across cancer lineages are Maturation of SSU-rRNA, Nucleolar large rRNA transcription by RNA polymerase I, and Transcription initiation at RNA polymerase I promoter. Each is linked with NOLC1 in more than 19 cancer types. Because this analysis shows association rather than direction, both NOLC1-to-partner and partner-to-NOLC1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Maturation of SSU-rRNA grouped by NOLC1-low versus NOLC1-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (NOLC1→partner) and Y-score (partner→NOLC1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Maturation of SSU-rRNA →	+0.147	+1.236	<.001	<.001	3	20
BONE	Nucleolar large rRNA transcription by RNA polymerase I →	+0.177	+1.410	<.001	<.001	3	20
PANCREAS	Transcription initiation at RNA polymerase I promoter →	+0.140	+1.269	<.001	<.001	3	19
BLOOD_Lymphoma	rRNA processing →	+0.111	+1.153	<.001	<.001	3	19
BLOOD_Lymphoma	rRNA metabolic process →	+0.105	+1.117	<.001	<.001	3	18
LUNG_SCLC	Ribosome biogenesis →	+0.122	+0.933	<.001	<.001	3	18

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,900 associations by consensus.

Maturation of SSU-rRNA by NOLC1 expression — BONE

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