NOL6

Across TCGA patient cohorts, NOL6 mutation is significantly associated with the total protein of many other genes, with 56 significant associations in total. COAD shows the largest number of these associations.

The most reproducible NOL6-associated genes across cancer lineages are eIF4E, JNK2, and PDCD4. Each is linked with NOL6 in more than 2 cancer types. Because this analysis shows association rather than direction, both NOL6-to-partner and partner-to-NOL6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eIF4E grouped by NOL6-low versus NOL6-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NOL6→partner) and Y-score (partner→NOL6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	eIF4E →	+0.253	+2.725	<.001	.003	3	3
BLCA	JNK2 →	-0.207	-3.000	.026	.036	3	2
BLCA	PDCD4 →	-0.470	-3.000	.039	.036	3	2
SKCM	JNK_pT183_Y185 →	-0.163	-3.169	.005	.017	3	2
SKCM	4E-BP1 →	+0.265	+2.115	.044	.018	3	2
UCEC	Cyclin-B1 →	+0.680	+3.807	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 56 associations by consensus.

eIF4E by NOL6 expression — COAD

Explore this box plot interactively →