NOL6

Across TCGA cell cohorts, NOL6 mutation is significantly associated with the RNA expression of many other genes, with 504 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible NOL6-associated genes across cancer lineages are ITLN2, VAX1, and GPRIN2. Each is linked with NOL6 in more than 1 cancer types. Because this analysis shows association rather than direction, both NOL6-to-partner and partner-to-NOL6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ITLN2 grouped by NOL6-low versus NOL6-high in BLOOD_Lymphoma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NOL6→partner) and Y-score (partner→NOL6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	ITLN2 →	+0.183	+3.717	<.001	.005	3	2
BLOOD_Leukemia	VAX1 →	+0.005	+2.450	.006	.007	3	2
BLOOD_Leukemia	GPRIN2 →	+0.024	+3.267	.001	.001	3	2
BLOOD_Leukemia	CLDN34 →	+0.027	+3.569	<.001	.009	3	2
LARGE_INTESTINE	GLO1 →	+0.644	+2.502	.001	.005	3	2
LARGE_INTESTINE	C12orf65 →	+0.444	+2.502	.002	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 504 associations by consensus.

ITLN2 by NOL6 expression — BLOOD_Lymphoma

Explore this box plot interactively →