NOL12

Across TCGA cell cohorts, NOL12 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,253 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible NOL12-associated GO terms across cancer lineages are Mitotic DNA replication checkpoint signaling, DNA replication checkpoint signaling, and Double-strand break repair via break-induced replication. Each is linked with NOL12 in more than 12 cancer types. Because this analysis shows association rather than direction, both NOL12-to-partner and partner-to-NOL12 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Mitotic DNA replication checkpoint signaling grouped by NOL12-low versus NOL12-high in SOFT_TISSUE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (NOL12→partner) and Y-score (partner→NOL12) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	Mitotic DNA replication checkpoint signaling →	+0.154	+0.802	<.001	.001	3	13
SOFT_TISSUE	DNA replication checkpoint signaling →	+0.138	+0.715	<.001	<.001	3	12
UPPER_AERODIGESTIVE_TRACT	Double-strand break repair via break-induced replication →	+0.246	+1.152	<.001	<.001	3	12
BONE	DNA strand elongation involved in DNA replication →	+0.168	+0.553	.006	.006	3	11
SOFT_TISSUE	Negative regulation of DNA-templated DNA replication →	+0.119	+0.894	.002	.001	3	11
OVARY	Immunoglobulin heavy chain V-D-J recombination →	+0.136	+0.535	<.001	<.001	3	11

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,253 associations by consensus.

Mitotic DNA replication checkpoint signaling by NOL12 expression — SOFT_TISSUE

Explore this box plot interactively →