NOL11

Across TCGA patient cohorts, NOL11 mutation is significantly associated with the RNA expression of many other genes, with 2,163 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NOL11-associated genes across cancer lineages are RNU6-644P, RN7SKP182, and RNU6-1305P. Each is linked with NOL11 in more than 1 cancer types. Because this analysis shows association rather than direction, both NOL11-to-partner and partner-to-NOL11 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-644P grouped by NOL11-low versus NOL11-high in HNSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NOL11→partner) and Y-score (partner→NOL11) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	RNU6-644P →	+0.575	+5.131	<.001	<.001	3	2
HNSC	RN7SKP182 →	+0.116	+4.424	.001	.008	3	2
SKCM	RNU6-1305P →	+0.302	+4.809	<.001	.001	3	2
SKCM	RNU6-432P →	+0.183	+5.634	<.001	.001	3	2
SKCM	TTTY22 →	+0.169	+5.452	<.001	<.001	3	2
BLCA	TRBVB →	+0.106	+5.814	<.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,163 associations by consensus.

RNU6-644P by NOL11 expression — HNSC

Explore this box plot interactively →