NOL11

Across TCGA patient cohorts, NOL11 mutation is significantly associated with the total protein of many other genes, with 21 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NOL11-associated genes across cancer lineages are EGFR_pY1068, A-Raf_pS299, and INPP4B. Each is linked with NOL11 in more than 1 cancer types. Because this analysis shows association rather than direction, both NOL11-to-partner and partner-to-NOL11 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR_pY1068 grouped by NOL11-low versus NOL11-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NOL11→partner) and Y-score (partner→NOL11) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.247	-2.087	.010	.005	3	1
UCEC	A-Raf_pS299 →	-0.144	-3.584	.001	.002	3	1
UCEC	INPP4B →	-0.332	-2.115	.007	.017	3	1
UCEC	JNK_pT183_Y185 →	-0.131	-1.664	.042	.023	3	1
UCEC	JNK2 →	+0.252	+1.678	<.001	.023	3	1
UCEC	Ku80 →	+0.215	+1.335	.017	.046	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 21 associations by consensus.

EGFR_pY1068 by NOL11 expression — UCEC

Explore this box plot interactively →