NOL10

Across TCGA patient cohorts, NOL10 mutation is significantly associated with the total protein of many other genes, with 19 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NOL10-associated genes across cancer lineages are ACC1, MEK1, and PCNA. Each is linked with NOL10 in more than 1 cancer types. Because this analysis shows association rather than direction, both NOL10-to-partner and partner-to-NOL10 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ACC1 grouped by NOL10-low versus NOL10-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NOL10→partner) and Y-score (partner→NOL10) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ACC1 →	+0.304	+3.183	.022	.009	3	2
UCEC	MEK1 →	+0.354	+1.906	.008	.015	3	2
UCEC	PCNA →	+0.227	+2.807	.004	.003	3	2
UCEC	14-3-3_beta →	-0.074	-2.295	.045	.033	3	1
UCEC	EGFR_pY1068 →	-0.204	-1.502	.027	.030	3	1
UCEC	FoxM1 →	+0.238	+2.736	.012	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 19 associations by consensus.

ACC1 by NOL10 expression — UCEC

Explore this box plot interactively →