NOL10

Across TCGA cell cohorts, NOL10 mutation is significantly associated with the RNA expression of many other genes, with 508 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible NOL10-associated genes across cancer lineages are IL17F, SNU13, and PRMT5. Each is linked with NOL10 in more than 1 cancer types. Because this analysis shows association rather than direction, both NOL10-to-partner and partner-to-NOL10 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, IL17F grouped by NOL10-low versus NOL10-high in URINARY_TRACT.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NOL10→partner) and Y-score (partner→NOL10) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	IL17F →	+0.056	+5.087	<.001	.004	3	1
LARGE_INTESTINE	SNU13 →	+0.503	+3.067	.001	.009	3	1
LARGE_INTESTINE	PRMT5 →	+0.594	+3.169	.001	.009	3	1
LARGE_INTESTINE	ADNP2 →	+0.936	+3.502	<.001	.001	3	1
LARGE_INTESTINE	METTL4 →	+0.665	+3.067	<.001	.009	3	1
LARGE_INTESTINE	SLC39A14 →	+0.765	+3.237	.003	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 508 associations by consensus.

IL17F by NOL10 expression — URINARY_TRACT

Explore this box plot interactively →