NOCT

Across TCGA pan-cancer cohorts, NOCT mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated NOCT data layer compared with 25 for mass-spec protein and 1 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher NOCT mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated NOCT expression acts as an unfavorable survival marker, although some lineages such as HNSC and PDAC show a favorable association.

HNSC, LUAD, and LSCC are the cancer types where NOCT mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Quartile	II,III,IV	0.922	0.572	.003	52	view →
LUAD	OS	Tertile	III,IV	0.282	0.931	.007	20	view →
LSCC	DFS	Median	III,IV	0.591	0.944	.009	5	view →
PDAC	DFS	Median	IV	0.741	0.203	.024	3	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

NOCT–HNSC (DFS)

Open the HNSC breakdown →