NOCT

Across TCGA pan-cancer cohorts, NOCT mass-spec protein differs between tumor and matched normal tissue in 4 of 18 cancer types tested, making tumor–normal expression one of NOCT’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where NOCT mass-spec protein is more highly expressed in tumor relative to normal tissue. In most cancer types NOCT is over-expressed in tumor.

HNSC, CCRCC, and LSCC are the cancer types where NOCT tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in NOCT mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	All	III,IV	+0.491	<.001	8	view →
CCRCC	All	II,III,IV	+0.181	.011	5	view →
LSCC	All	All	+0.158	.002	5	view →
LUAD	All	II,III,IV	+0.220	.024	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 4 strongest of 4 lineages.

NOCT–HNSC

Open the HNSC breakdown →