NOCT

Across TCGA patient cohorts, NOCT mutation is significantly associated with the total protein of many other genes, with 24 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NOCT-associated genes across cancer lineages are ER-alpha, FOXO3a_pS318_S321, and JNK2. Each is linked with NOCT in more than 1 cancer types. Because this analysis shows association rather than direction, both NOCT-to-partner and partner-to-NOCT results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ER-alpha grouped by NOCT-low versus NOCT-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NOCT→partner) and Y-score (partner→NOCT) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ER-alpha →	-0.964	-3.000	.015	.036	3	1
UCEC	FOXO3a_pS318_S321 →	-0.145	-3.169	.016	.018	3	1
UCEC	JNK2 →	+0.345	+2.459	<.001	.020	3	1
UCEC	Ku80 →	+0.302	+3.598	.008	.001	3	1
UCEC	MSH2 →	-0.455	-2.312	<.001	.034	3	1
UCEC	p62 Lck ligand →	+0.600	+3.584	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 24 associations by consensus.

ER-alpha by NOCT expression — UCEC

Explore this box plot interactively →