NOCT

Across TCGA cell cohorts, NOCT RNA expression is significantly associated with the go_rna of many other GO terms, with 4,522 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible NOCT-associated GO terms across cancer lineages are Positive regulation of SREBP signaling pathway, Regulation of hippo signaling, and Transcription by RNA polymerase III. Each is linked with NOCT in more than 11 cancer types. Because this analysis shows association rather than direction, both NOCT-to-partner and partner-to-NOCT results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of SREBP signaling pathway grouped by NOCT-low versus NOCT-high in SKIN.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (NOCT→partner) and Y-score (partner→NOCT) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	Positive regulation of SREBP signaling pathway →	+0.097	+0.788	<.001	<.001	3	12
BONE	Regulation of hippo signaling →	+0.080	+0.742	.001	<.001	3	11
BLOOD_Myeloma	Transcription by RNA polymerase III →	+0.082	+0.970	.001	<.001	3	11
LUNG_NSCLC_LUSC	Regulation of modification of postsynaptic structure →	+0.167	+0.728	.005	.004	3	11
BONE	Negative regulation of vascular associated smooth muscle cell apoptotic process →	+0.229	+0.865	.001	<.001	3	10
BONE	Regulation of clathrin-dependent endocytosis →	+0.121	+0.905	<.001	.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,522 associations by consensus.

Positive regulation of SREBP signaling pathway by NOCT expression — SKIN

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