Across TCGA patient cohorts, NOC4L mutation is significantly associated with the total protein of many other genes, with 13 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NOC4L-associated genes across cancer lineages are Cyclin-B1, FOXO3a_pS318_S321, and p62 Lck ligand. Each is linked with NOC4L in more than 1 cancer types. Because this analysis shows association rather than direction, both NOC4L-to-partner and partner-to-NOC4L results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NOC4L→partner) and Y-score (partner→NOC4L) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Cyclin-B1 →	+0.726	+3.169	.010	.019	3	2
UCEC	FOXO3a_pS318_S321 →	-0.136	-2.312	.030	.034	3	1
UCEC	p62 Lck ligand →	+0.574	+3.459	<.001	.005	3	1
UCEC	Caspase-8 →	-0.266	-2.321	.035	.035	3	1
UCEC	C-Raf →	+0.208	+2.321	.003	.035	3	1
UCEC	ERK2 →	+0.223	+3.459	.021	.005	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 13 associations by consensus.

Exploration

NOC4L survival (RNA) · tumor vs normal (RNA) · all NOC4L data types