Across TCGA cell cohorts, NOC4L mutation is significantly associated with the RNA expression of many other genes, with 15 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible NOC4L-associated genes across cancer lineages are LCN1, PDHA2, and OR8B12. Each is linked with NOC4L in more than 1 cancer types. Because this analysis shows association rather than direction, both NOC4L-to-partner and partner-to-NOC4L results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NOC4L→partner) and Y-score (partner→NOC4L) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	LCN1 →	+0.529	+5.029	<.001	.006	3	1
LUNG_SCLC	PDHA2 →	+0.026	+5.029	<.001	.006	3	1
LUNG_SCLC	OR8B12 →	+0.021	+5.029	.001	.006	3	1
BLOOD_Leukemia	RGR →	+0.031	+4.269	<.001	.002	3	1
BLOOD_Leukemia	ADIPOQ →	+0.023	+4.269	<.001	.002	3	1
BLOOD_Leukemia	CCT8L2 →	+0.009	+3.874	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 15 associations by consensus.

Exploration

NOC4L survival (RNA) · tumor vs normal (RNA) · all NOC4L data types