NOB1

Across TCGA pan-cancer cohorts, NOB1 mass-spec protein is linked to patient survival in 7 of 34 cancer types, making it a survival-associated NOB1 data layer compared with 24 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher NOB1 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated NOB1 expression acts as an unfavorable survival marker, although some lineages such as GBM and LSCC show a favorable association.

LUAD, GBM, and LSCC are the cancer types where NOB1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	DFS	Median	II,III,IV	0.195	0.814	.001	16	view →
GBM	DFS	Median	All	0.514	0.235	.002	11	view →
LSCC	DFS	Median	II,III,IV	0.854	0.522	.006	6	view →
UCEC	DFS	Median	All	1.000	0.935	.020	6	view →
HNSC	OS	Median	II,III,IV	0.992	0.935	.028	5	view →
CCRCC	OS	Quartile	All	0.583	1.000	.019	2	view →
PDAC	DFS	Median	II,III,IV	0.459	0.321	.030	2	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

NOB1–LUAD (DFS)

Open the LUAD breakdown →