NOA1

Across TCGA pan-cancer cohorts, NOA1 Mutation is linked to patient survival in 4 of 34 cancer types, making it a survival-associated NOA1 data layer compared with 22 for mass-spec protein and 5 for mass-spec protein.

The strongest signal is observed in liver hepatocellular carcinoma (LIHC), where higher NOA1 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated NOA1 expression acts as an unfavorable survival marker.

LIHC, ESCA, and PRAD are the cancer types where NOA1 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LIHC	OS	Median	All	0.028	0.777	<.001	24	view →
ESCA	OS	Median	II,III,IV	0.248	0.686	.019	9	view →
PRAD	DFS	Median	All	0.085	0.774	<.001	6	view →
SKCM	DFS	Median	All	0.136	0.757	.006	6	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

NOA1–LIHC (OS)

Open the LIHC breakdown →