NOA1

Across TCGA patient cohorts, NOA1 mutation is significantly associated with the total protein of many other genes, with 20 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NOA1-associated genes across cancer lineages are eIF4E, c-Jun_pS73, and FoxM1. Each is linked with NOA1 in more than 1 cancer types. Because this analysis shows association rather than direction, both NOA1-to-partner and partner-to-NOA1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eIF4E grouped by NOA1-low versus NOA1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NOA1→partner) and Y-score (partner→NOA1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eIF4E →	+0.209	+2.335	.023	.018	3	2
UCEC	c-Jun_pS73 →	-0.173	-2.986	.012	.035	3	2
UCEC	FoxM1 →	+0.231	+2.321	.041	.033	3	1
UCEC	FOXO3a_pS318_S321 →	-0.147	-3.312	.007	.010	3	1
UCEC	INPP4B →	-0.277	-2.999	.049	.035	3	1
UCEC	Myosin-IIa_pS1943 →	+0.193	+1.598	.032	.044	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 20 associations by consensus.

eIF4E by NOA1 expression — UCEC

Explore this box plot interactively →