NNMT

Across TCGA pan-cancer cohorts, NNMT mass-spec protein is linked to patient survival in 7 of 34 cancer types, making it a survival-associated NNMT data layer compared with 22 for mass-spec protein and 5 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher NNMT mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated NNMT expression acts as an unfavorable survival marker, although some lineages such as LUAD show a favorable association.

CCRCC, PDAC, and GBM are the cancer types where NNMT mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	OS	Tertile	All	0.692	0.961	<.001	43	view →
PDAC	DFS	Tertile	All	0.212	0.468	.020	17	view →
GBM	DFS	Quartile	All	0.524	0.922	<.001	13	view →
COAD	DFS	Median	II,III,IV	0.879	1.000	.019	12	view →
LSCC	DFS	Tertile	II,III,IV	0.547	0.948	.006	8	view →
LUAD	OS	Median	All	0.902	0.666	.037	2	view →
HNSC	DFS	Tertile	II,III,IV	0.565	0.774	.041	1	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

NNMT–CCRCC (OS)

Open the CCRCC breakdown →