NNAT

Across TCGA patient cohorts, NNAT mutation is significantly associated with the RNA expression of many other genes, with 608 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NNAT-associated genes across cancer lineages are CTBP2P10, LINC00538, and MTND5P17. Each is linked with NNAT in more than 1 cancer types. Because this analysis shows association rather than direction, both NNAT-to-partner and partner-to-NNAT results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CTBP2P10 grouped by NNAT-low versus NNAT-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NNAT→partner) and Y-score (partner→NNAT) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	CTBP2P10 →	+0.017	+4.010	<.001	.007	3	1
UCEC	LINC00538 →	+0.052	+2.542	.007	.002	3	1
CESC	MTND5P17 →	+0.035	+5.812	<.001	.003	3	1
CESC	ELAVL4-AS1 →	+0.064	+5.103	<.001	.008	3	1
CESC	RN7SL658P →	+0.178	+6.144	<.001	.001	3	1
CESC	MIR4510 →	+0.400	+6.342	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 608 associations by consensus.

CTBP2P10 by NNAT expression — UCEC

Explore this box plot interactively →