NNAT

Across TCGA patient cohorts, NNAT mutation is significantly associated with the total protein of many other genes, with 10 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NNAT-associated genes across cancer lineages are Fibronectin, Notch1, and PDCD4. Each is linked with NNAT in more than 1 cancer types. Because this analysis shows association rather than direction, both NNAT-to-partner and partner-to-NNAT results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Fibronectin grouped by NNAT-low versus NNAT-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NNAT→partner) and Y-score (partner→NNAT) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Fibronectin →	-0.326	-2.321	.049	.035	3	1
UCEC	Notch1 →	+0.222	+2.321	.001	.035	3	1
UCEC	PDCD4 →	-0.564	-2.321	.017	.035	3	1
UCEC	PTEN →	-0.572	-3.459	.004	.005	3	1
UCEC	Rad50 →	-0.316	-3.459	.009	.005	3	1
UCEC	p90 RSK →	+0.317	+3.179	<.001	.010	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 10 associations by consensus.

Fibronectin by NNAT expression — UCEC

Explore this box plot interactively →