NMU

Across TCGA patient cohorts, NMU mutation is significantly associated with the RNA expression of many other genes, with 89 significant associations in total. SKCM shows the largest number of these associations.

The most reproducible NMU-associated genes across cancer lineages are GNG10P1, RNU4-65P, and RN7SKP286. Each is linked with NMU in more than 1 cancer types. Because this analysis shows association rather than direction, both NMU-to-partner and partner-to-NMU results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GNG10P1 grouped by NMU-low versus NMU-high in LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NMU→partner) and Y-score (partner→NMU) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUSC	GNG10P1 →	+0.225	+5.273	.002	.006	3	2
SKCM	RNU4-65P →	+0.210	+4.328	<.001	.007	3	2
SKCM	RN7SKP286 →	+0.080	+5.810	<.001	<.001	3	2
SKCM	LINC02509 →	+0.311	+4.328	<.001	.007	3	2
BRCA	MIR548AP →	+0.322	+8.055	<.001	.007	3	1
BRCA	TTTY7B →	+0.024	+8.471	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 89 associations by consensus.

GNG10P1 by NMU expression — LUSC

Explore this box plot interactively →