Across TCGA pan-cancer cohorts, NMTRQ-TTG12-1 RNA differs between tumor and matched normal tissue in 2 of 18 cancer types tested, making tumor–normal expression one of NMTRQ-TTG12-1’s most consistent transcriptional readouts.
The strongest signal is observed in breast invasive carcinoma (BRCA), where NMTRQ-TTG12-1 RNA is repressed in tumor relative to normal tissue. In most cancer types NMTRQ-TTG12-1 is over-expressed in tumor, although a few such as BRCA and KIRC show the opposite, repressed pattern.
BRCA and KIRC are the cancer types where NMTRQ-TTG12-1 tumor–normal differential expression is most reproducible.