NMT2

Across TCGA patient cohorts, NMT2 mutation is significantly associated with the total protein of many other genes, with 48 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NMT2-associated genes across cancer lineages are 4E-BP1, mTOR_pS2448, and PCNA. Each is linked with NMT2 in more than 2 cancer types. Because this analysis shows association rather than direction, both NMT2-to-partner and partner-to-NMT2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 4E-BP1 grouped by NMT2-low versus NMT2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NMT2→partner) and Y-score (partner→NMT2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	4E-BP1 →	+0.280	+3.459	.002	.005	3	3
UCEC	mTOR_pS2448 →	-0.155	-2.523	.002	<.001	3	2
UCEC	PCNA →	+0.265	+3.169	<.001	<.001	3	2
UCEC	STAT3_pY705 →	-0.387	-2.137	<.001	.001	3	2
UCEC	BRD4 →	+0.242	+3.459	.010	.004	3	2
UCEC	EGFR →	-0.151	-3.295	.005	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 48 associations by consensus.

4E-BP1 by NMT2 expression — UCEC

Explore this box plot interactively →