NMT1

Across TCGA pan-cancer cohorts, NMT1 mass-spec protein is linked to patient survival in 7 of 34 cancer types, making it a survival-associated NMT1 data layer compared with 22 for mass-spec protein and 9 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher NMT1 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated NMT1 expression acts as an unfavorable survival marker, although some lineages such as LUAD and LSCC show a favorable association.

HNSC, PDAC, and CCRCC are the cancer types where NMT1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Quartile	All	0.167	0.949	.010	46	view →
PDAC	OS	Median	All	0.472	0.674	.015	20	view →
CCRCC	DFS	Quartile	III,IV	0.562	0.866	.011	16	view →
UCEC	DFS	Median	II,III,IV	0.502	0.861	.023	6	view →
GBM	OS	Tertile	All	0.712	0.902	.017	3	view →
LUAD	DFS	Median	III,IV	0.716	0.332	.011	3	view →
LSCC	DFS	Median	II,III,IV	0.963	0.867	.041	1	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

NMT1–HNSC (DFS)

Open the HNSC breakdown →