NMT1

Across TCGA patient cohorts, NMT1 mutation is significantly associated with the total protein of many other genes, with 16 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NMT1-associated genes across cancer lineages are JNK_pT183_Y185, Ku80, and MEK1. Each is linked with NMT1 in more than 1 cancer types. Because this analysis shows association rather than direction, both NMT1-to-partner and partner-to-NMT1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, JNK_pT183_Y185 grouped by NMT1-low versus NMT1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NMT1→partner) and Y-score (partner→NMT1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	JNK_pT183_Y185 →	-0.177	-2.102	.016	.019	3	1
UCEC	Ku80 →	+0.296	+2.128	.004	.010	3	1
UCEC	MEK1 →	+0.441	+2.700	.005	.006	3	1
UCEC	Notch1 →	+0.177	+1.750	.003	.049	3	1
UCEC	p62 Lck ligand →	+0.295	+3.331	.038	.005	3	1
UCEC	PCNA →	+0.217	+2.807	.021	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 16 associations by consensus.

JNK_pT183_Y185 by NMT1 expression — UCEC

Explore this box plot interactively →