Across TCGA patient cohorts, NMS mutation is significantly associated with the total protein of many other genes, with 9 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NMS-associated genes across cancer lineages are ACC1, ASNS, and Cyclin-B1. Each is linked with NMS in more than 1 cancer types. Because this analysis shows association rather than direction, both NMS-to-partner and partner-to-NMS results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NMS→partner) and Y-score (partner→NMS) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ACC1 →	+0.424	+3.000	.043	.037	3	1
UCEC	ASNS →	+0.451	+3.000	.030	.037	3	1
UCEC	Cyclin-B1 →	+0.831	+3.000	.010	.037	3	1
UCEC	Di-Ras3 →	-0.231	-3.000	.007	.037	3	1
SKCM	A-Raf_pS299 →	+0.227	+3.000	.005	.036	1	2
UCEC	TFRC →	+0.913	+3.000	.002	.037	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 9 associations by consensus.

Exploration

NMS survival (RNA) · tumor vs normal (RNA) · all NMS data types