NMRK2

Across TCGA patient cohorts, NMRK2 mutation is significantly associated with the total protein of many other genes, with 7 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NMRK2-associated genes across cancer lineages are FOXO3a_pS318_S321, Acetyl-a-Tubulin-Lys40, and JNK2. Each is linked with NMRK2 in more than 1 cancer types. Because this analysis shows association rather than direction, both NMRK2-to-partner and partner-to-NMRK2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FOXO3a_pS318_S321 grouped by NMRK2-low versus NMRK2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NMRK2→partner) and Y-score (partner→NMRK2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	FOXO3a_pS318_S321 →	-0.165	-2.999	.016	.035	3	1
UCEC	Acetyl-a-Tubulin-Lys40 →	+0.588	+3.169	.035	.020	3	1
UCEC	JNK2 →	+0.333	+3.169	.002	.020	3	1
UCEC	Notch1 →	+0.267	+3.009	<.001	.019	3	1
UCEC	TFRC →	+0.720	+3.169	.013	.020	3	1
UCEC	PDCD4 →	-1.085	-3.160	<.001	.019	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

FOXO3a_pS318_S321 by NMRK2 expression — UCEC

Explore this box plot interactively →