NMNAT2

Across TCGA patient cohorts, NMNAT2 mutation is significantly associated with the RNA expression of many other genes, with 2,181 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NMNAT2-associated genes across cancer lineages are RNA5SP199, RNU6-1279P, and FANCC. Each is linked with NMNAT2 in more than 1 cancer types. Because this analysis shows association rather than direction, both NMNAT2-to-partner and partner-to-NMNAT2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNA5SP199 grouped by NMNAT2-low versus NMNAT2-high in READ.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NMNAT2→partner) and Y-score (partner→NMNAT2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
READ	RNA5SP199 →	+0.612	+5.039	<.001	.008	3	2
READ	RNU6-1279P →	+0.427	+5.421	<.001	.005	3	2
UCEC	FANCC →	+0.412	+2.137	.001	.001	3	2
UCEC	ABHD3 →	+0.578	+2.928	.001	<.001	3	2
UCEC	PWWP3A →	+0.621	+2.148	<.001	<.001	3	2
UCEC	GFI1 →	+0.404	+2.158	.002	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,181 associations by consensus.

RNA5SP199 by NMNAT2 expression — READ

Explore this box plot interactively →