NMNAT2

Across TCGA patient cohorts, NMNAT2 mutation is significantly associated with the total protein of many other genes, with 30 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NMNAT2-associated genes across cancer lineages are GATA6, Tuberin, and ATM. Each is linked with NMNAT2 in more than 1 cancer types. Because this analysis shows association rather than direction, both NMNAT2-to-partner and partner-to-NMNAT2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GATA6 grouped by NMNAT2-low versus NMNAT2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NMNAT2→partner) and Y-score (partner→NMNAT2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	GATA6 →	-0.168	-3.307	.004	.009	3	2
UCEC	Tuberin →	+0.239	+1.415	.018	.046	3	2
UCEC	ATM →	-0.612	-2.571	<.001	.010	3	2
SKCM	4E-BP1_pS65 →	+0.300	+3.182	.002	.009	3	1
UCEC	ERK2 →	+0.260	+3.584	<.001	.002	3	1
UCEC	JNK2 →	+0.314	+2.817	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 30 associations by consensus.

GATA6 by NMNAT2 expression — UCEC

Explore this box plot interactively →