NMNAT2

Across TCGA cell cohorts, NMNAT2 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,601 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible NMNAT2-associated GO terms across cancer lineages are Regulation of intracellular transport, Regulation of cell-substrate junction organization, and Regulation of proteolysis. Each is linked with NMNAT2 in more than 12 cancer types. Because this analysis shows association rather than direction, both NMNAT2-to-partner and partner-to-NMNAT2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of intracellular transport grouped by NMNAT2-low versus NMNAT2-high in SKIN.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (NMNAT2→partner) and Y-score (partner→NMNAT2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	Regulation of intracellular transport →	+0.061	+1.248	<.001	<.001	3	13
STOMACH	Regulation of cell-substrate junction organization →	+0.119	+1.717	<.001	.006	3	10
LARGE_INTESTINE	Regulation of proteolysis →	+0.085	+0.994	<.001	.001	3	9
OESOPHAGUS	Regulation of intracellular protein transport →	+0.073	+2.384	<.001	<.001	3	9
OESOPHAGUS	Negative regulation of syncytium formation by plasma membrane fusion →	+0.142	+2.447	.005	.005	2	10
OESOPHAGUS	Positive regulation of intracellular protein transport →	+0.083	+2.363	.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,601 associations by consensus.

Regulation of intracellular transport by NMNAT2 expression — SKIN

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