NMNAT2

Across TCGA cell cohorts, NMNAT2 mutation is significantly associated with the RNA expression of many other genes, with 4 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible NMNAT2-associated genes across cancer lineages are PRSS54, SMCP, and C11orf97. Each is linked with NMNAT2 in more than 1 cancer types. Because this analysis shows association rather than direction, both NMNAT2-to-partner and partner-to-NMNAT2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PRSS54 grouped by NMNAT2-low versus NMNAT2-high in BLOOD_Lymphoma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NMNAT2→partner) and Y-score (partner→NMNAT2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	PRSS54 →	+0.046	+4.867	<.001	.009	3	1
BLOOD_Lymphoma	SMCP →	+0.034	+4.867	<.001	.009	3	1
BLOOD_Lymphoma	C11orf97 →	+2.118	+5.209	<.001	.005	3	1
LARGE_INTESTINE	CD300H →	+0.039	+4.415	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 4 strongest of 4 associations by consensus.

PRSS54 by NMNAT2 expression — BLOOD_Lymphoma

Explore this box plot interactively →