NMNAT2

Across TCGA cell cohorts, NMNAT2 mutation is significantly associated with the mutation status of many other genes, with 2,410 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible NMNAT2-associated genes across cancer lineages are GCNA, FARP1, and ANO2. Each is linked with NMNAT2 in more than 1 cancer types. Because this analysis shows association rather than direction, both NMNAT2-to-partner and partner-to-NMNAT2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GCNA grouped by NMNAT2-low versus NMNAT2-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NMNAT2→partner) and Y-score (partner→NMNAT2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	GCNA →	+4.187	+5.000	.008	.008	1	2
LUNG_NSCLC_LUAD	FARP1 →	+5.772	+5.772	.002	.002	1	2
LUNG_NSCLC_LUAD	ANO2 →	+4.187	+5.000	.008	.008	1	2
LARGE_INTESTINE	PDCD7 →	+4.329	+4.329	.001	.001	1	2
LARGE_INTESTINE	NLRP1 →	+2.574	+4.182	.003	.003	1	2
LARGE_INTESTINE	NLRP4 →	+2.744	+4.321	.002	.002	1	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,410 associations by consensus.

GCNA by NMNAT2 expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →