NMNAT1

Across TCGA pan-cancer cohorts, NMNAT1 mass-spec protein is linked to patient survival in 3 of 34 cancer types, making it a survival-associated NMNAT1 data layer compared with 24 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher NMNAT1 mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated NMNAT1 expression acts as an unfavorable survival marker, although some lineages such as HNSC and CCRCC show a favorable association.

HNSC, PDAC, and CCRCC are the cancer types where NMNAT1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Tertile	All	0.947	0.166	.010	38	view →
PDAC	DFS	Median	III,IV	0.542	0.888	.006	6	view →
CCRCC	OS	Median	All	0.915	0.757	.005	3	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

NMNAT1–HNSC (OS)

Open the HNSC breakdown →