NMNAT1

Across TCGA patient cohorts, NMNAT1 mutation is significantly associated with the RNA expression of many other genes, with 360 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NMNAT1-associated genes across cancer lineages are RN7SKP286, EZH2P1, and BTF3L4P4. Each is linked with NMNAT1 in more than 1 cancer types. Because this analysis shows association rather than direction, both NMNAT1-to-partner and partner-to-NMNAT1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RN7SKP286 grouped by NMNAT1-low versus NMNAT1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NMNAT1→partner) and Y-score (partner→NMNAT1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RN7SKP286 →	+0.048	+4.153	<.001	.005	3	2
UCEC	EZH2P1 →	+0.333	+2.427	<.001	<.001	3	2
SKCM	BTF3L4P4 →	+0.096	+4.680	<.001	.007	3	2
HNSC	TAAR4P →	+0.098	+5.505	<.001	.004	3	2
HNSC	RNY3P11 →	+0.473	+5.505	<.001	.004	3	2
UCEC	PMS2P2 →	+0.254	+2.906	.002	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 360 associations by consensus.

RN7SKP286 by NMNAT1 expression — UCEC

Explore this box plot interactively →