NMNAT1

Across TCGA patient cohorts, NMNAT1 mutation is significantly associated with the total protein of many other genes, with 15 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NMNAT1-associated genes across cancer lineages are mTOR_pS2448, eIF4G, and NDRG1_pT346. Each is linked with NMNAT1 in more than 1 cancer types. Because this analysis shows association rather than direction, both NMNAT1-to-partner and partner-to-NMNAT1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, mTOR_pS2448 grouped by NMNAT1-low versus NMNAT1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NMNAT1→partner) and Y-score (partner→NMNAT1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	mTOR_pS2448 →	-0.200	-2.459	.005	.020	3	2
UCEC	eIF4G →	+0.360	+3.169	.016	.019	3	1
UCEC	NDRG1_pT346 →	-0.542	-2.999	.022	.035	3	1
UCEC	p38-MAPK_pT180_Y182 →	-0.720	-2.446	<.001	.020	3	1
UCEC	PCNA →	+0.283	+2.459	.006	.020	3	1
UCEC	PKC-b-II_pS660 →	-0.295	-2.459	.027	.020	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 15 associations by consensus.

mTOR_pS2448 by NMNAT1 expression — UCEC

Explore this box plot interactively →