NMNAT1

Across TCGA cell cohorts, NMNAT1 RNA expression is significantly associated with the go_rna of many other GO terms, with 2,758 significant associations in total. BONE shows the largest number of these associations.

The most reproducible NMNAT1-associated GO terms across cancer lineages are Negative regulation of organelle assembly, Autophagosome organization, and Positive regulation of autophagy. Each is linked with NMNAT1 in more than 10 cancer types. Because this analysis shows association rather than direction, both NMNAT1-to-partner and partner-to-NMNAT1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of organelle assembly grouped by NMNAT1-low versus NMNAT1-high in LUNG_NSCLC_LUAD.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (NMNAT1→partner) and Y-score (partner→NMNAT1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	Negative regulation of organelle assembly →	+0.049	+0.508	<.001	<.001	3	11
LUNG_NSCLC_LUAD	Autophagosome organization →	+0.042	+0.648	<.001	<.001	3	10
SKIN	Positive regulation of autophagy →	+0.029	+0.603	.004	.007	3	10
LUNG_SCLC	Response to methionine →	+0.120	+0.866	.009	.005	2	10
LUNG_SCLC	Cellular response to methionine →	+0.120	+0.866	.009	.005	2	10
LIVER	Regulation of protein binding →	+0.100	+0.776	.005	.006	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,758 associations by consensus.

Negative regulation of organelle assembly by NMNAT1 expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →