NMI

Across TCGA patient cohorts, NMI mutation is significantly associated with the total protein of many other genes, with 26 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NMI-associated genes across cancer lineages are eIF4E, JNK2, and Ku80. Each is linked with NMI in more than 1 cancer types. Because this analysis shows association rather than direction, both NMI-to-partner and partner-to-NMI results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eIF4E grouped by NMI-low versus NMI-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NMI→partner) and Y-score (partner→NMI) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eIF4E →	+0.209	+3.013	.033	.018	3	1
UCEC	JNK2 →	+0.283	+2.834	.002	.034	3	1
UCEC	Ku80 →	+0.321	+2.598	.003	.006	3	1
UCEC	MEK1 →	+0.510	+3.700	.002	.001	3	1
UCEC	NDRG1_pT346 →	-0.564	-2.584	.013	.011	3	1
UCEC	p62 Lck ligand →	+0.440	+3.179	.003	.010	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 26 associations by consensus.

eIF4E by NMI expression — UCEC

Explore this box plot interactively →