NME8

Across TCGA patient cohorts, NME8 mutation is significantly associated with the total protein of many other genes, with 59 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NME8-associated genes across cancer lineages are Cyclin-B1, Rab25, and FASN. Each is linked with NME8 in more than 2 cancer types. Because this analysis shows association rather than direction, both NME8-to-partner and partner-to-NME8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Cyclin-B1 grouped by NME8-low versus NME8-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NME8→partner) and Y-score (partner→NME8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Cyclin-B1 →	+0.776	+3.807	<.001	<.001	3	3
UCEC	Rab25 →	-0.440	-3.906	<.001	<.001	3	3
LUSC	FASN →	+0.412	+3.169	.038	.018	3	2
LUSC	Akt →	-0.402	-2.312	.030	.035	3	2
LUSC	Chk2_pT68 →	+0.119	+2.331	.028	.019	3	2
LUSC	c-Met_pY1235 →	+0.071	+3.027	.049	.018	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 59 associations by consensus.

Cyclin-B1 by NME8 expression — UCEC

Explore this box plot interactively →