NME8

Across TCGA cell cohorts, NME8 mutation is significantly associated with the RNA expression of many other genes, with 376 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible NME8-associated genes across cancer lineages are ACBD5, ZNF330, and DCK. Each is linked with NME8 in more than 1 cancer types. Because this analysis shows association rather than direction, both NME8-to-partner and partner-to-NME8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ACBD5 grouped by NME8-low versus NME8-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NME8→partner) and Y-score (partner→NME8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	ACBD5 →	+0.775	+3.169	.001	.006	3	2
LARGE_INTESTINE	ZNF330 →	+0.464	+3.237	.002	.003	3	2
LARGE_INTESTINE	DCK →	+0.628	+3.321	<.001	.002	3	2
OESOPHAGUS	OR8A1 →	+0.115	+3.836	.007	.004	3	1
OESOPHAGUS	OR10D3 →	+0.166	+3.836	<.001	.004	3	1
SKIN	CHRNB3 →	+0.005	+2.560	<.001	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 376 associations by consensus.

ACBD5 by NME8 expression — LARGE_INTESTINE

Explore this box plot interactively →